Plot: Charlotte, an older woman who has spent the last six months taking care of her dying husband Eddie, is rushed to Princeton Plainsboro after collapsing from respiratory failure. The couple becomes a double mystery for the team when Eddie begins to improve as Charlotte’s condition worsens. The previously unthinkable becomes real when it seems that Charlotte will die before Eddie, and the team will be forced to make a difficult decision.
Plot: House is injured in a motorcycle accident in Middletown and finds himself in bed next to a patient suffering from complete paralysis. As House transfers the patient to Princeton to determine what's wrong with him, Wilson tries to find out why House was in New York.
Plot: Nursing-home worker Morgan fakes sick to get House's attention after the home’s pet cat sleeps next to her. It seems that the cat only pays a visit to people if they are about to die – and does so with alarming accuracy. While House dismisses Morgan as a nut job, he is intrigued by her theory on the kiss-of-death cat, and sets out to disprove it. When Morgan falls seriously ill, he and the team are forced to get to the bottom of both mysteries.
